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Within 72 Hours of Quitting While nicotine withdrawal symptoms are typically at their worst during the first 72 hours of quitting, the anxiety, irritability, and anger will usually peak within 24 to 48 hours and gradually subside from there

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Preventive Services Task Force recommendation statement

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This is consistent with the GRADE approach, in which strong recommendations are sometimes made with low-certainty evidence combined with high certainty of harm or resource implications, and with the value that the task force places on using scarce primary care resources wisely